Product Description

Background:Coronavirus encodes the 2"-O-MTase（2"O Methyltransferase） that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2"O-methyltransferase (2"O-MTase) is highly conserved. The conserved 2"O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design in an expanding Coronavirus outbreak setting, such as COVID-19. Targeting on the 2"O-methylation pathway on SARS-CoV replication and pathogenesis can be the treatment options for vaccine and anti-viral durgs development which can against SARS-CoV-2，SARS-CoV, MERS-CoV or other RNA and DNA viruses..Formulation:Lyophilized from sterile PBS, pH 7.4.Purity:> 85 % as determined by reducing SDS-PAGE.Endotoxin:< 1.0 EU per µg as determined by the LAL method.Shipping:This product is provided as lyophilized powder which is shipped with ice packs.Storage:Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.

More Details:Sequence:Ser6799-Asn7096Fusion Tag:C-HisAccession:YP_009724390.1Species:VirusExpression System:E. coliMol Mass:33.46 kDa.

Synonyms:Methyltransferase, ME

Datasheet

FOR RESEARCH USE ONLY, NOT FOR USE IN DIAGNOSTIC PROCEDURES.Manufactured by: Elabscience